(19)

(11)

EP 1 212 427 A2

(12)

(88) Date of publication A3: 02.08.2001 (43) Date of publication: 12.06.2002 Bulletin 2002/24 (21) Application number: 00969255.9 (22) Date of filing: 14.09.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C12N 15/62, C07K 14/21, C07K 16/12, A61K 39/02, A61K 39/40, A61K 48/00, G01N 33/53 (86) International application number: PCT/EP0009/036 (87) International publication number: WO 0119/997 (22.03.2001 Gazette 2001/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.09.1999 GB 9921692 (71) Applicant: SmithKline Beecham Biologics SA 1330 Rixensart (BE)	(72) Inventor: THONNARD, JoelleSmithKline Beecham Biologic. S.A. B-1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)