(19)

(11)

EP 1 214 098 A1

(12)

(43) Date of publication: 19.06.2002 Bulletin 2002/25 (21) Application number: 00966810.4 (22) Date of filing: 22.09.2000

(51) International Patent Classification (IPC)7: A61K 48/00, C12N 15/00, C12N 15/63, C12N 15/86 (86) International application number: PCT/US0026/079 (87) International publication number: WO 0121/216 (29.03.2001 Gazette 2001/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.09.1999 US 156104 P (71) Applicant: THE UAB RESEARCH FOUNDATION Birmingham, AL 35294-0111 (US)	(72) Inventor: CURIEL, David, T. Birmingham, AL 35222 (US) (74) Representative: Wilkinson, Stephen John  Stevens, Hewlett & Perkins1 St. Augustine's Place Bristol BS1 4UD Bristol BS1 4UD (GB)