(19)

(11)

EP 1 214 342 A1

(12)

(43) Date of publication: 19.06.2002 Bulletin 2002/25 (21) Application number: 00961622.8 (22) Date of filing: 07.09.2000

(51) International Patent Classification (IPC)7: C07K 14/47, C07K 14/705, C12N 5/10, C12N 15/63, C12N 15/64 (86) International application number: PCT/US0024/517 (87) International publication number: WO 0118/049 (15.03.2001 Gazette 2001/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.09.1999 US 152932 P 14.03.2000 US 189032 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: NI, Jian Rockville, MD 20853 (US) SHI, Yanggu Gaithersburg, MD 20878 (US) RUBEN, Steven, M. Olney, MD 20832 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)