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(11)

EP 1 214 429 A1

(12)

(43) Date of publication: 19.06.2002 Bulletin 2002/25 (21) Application number: 00968378.0 (22) Date of filing: 21.09.2000

(51) International Patent Classification (IPC)7: C12N 15/67, C12Q 1/68, G01N 33/50 // (C12N15/12, C07K14:735, C12N5:10, A01K67:027, A61K38:17) (86) International application number: PCT/US0025/877 (87) International publication number: WO 0121/816 (29.03.2001 Gazette 2001/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.09.1999 US 154924 P (71) Applicants: ISIS INNOVATION LIMITED Summertown,Oxford OX2 7BZ (GB) Beth Israel Deaconess Medical Center, Inc. Boston, MA 02215 (US)	(72) Inventors: KINET, Jean-Pierre Lexington, MA 02421 (US) DONNADIEU, Emmanuel F-92100 Boulogne (FR) JOUVIN, Marie-Helene Brookline, MA 02446 (US) COOKSON, William Oxford OX3 9DU (GB) MOFFATT, Miriam Fleur Bicester,Oxon OX6 0XR (GB) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)