(19)

(11)

EP 1 214 436 A2

(12)

(88) Date of publication A3: 04.10.2001 (43) Date of publication: 19.06.2002 Bulletin 2002/25 (21) Application number: 00967766.7 (22) Date of filing: 25.09.2000

(51) International Patent Classification (IPC)7: C12N 15/82, C07K 14/415, C07K 16/16, C12N 15/29, C12N 15/11, C12N 15/62, C12N 5/14 (86) International application number: PCT/EP0009/325 (87) International publication number: WO 0121/644 (29.03.2001 Gazette 2001/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.09.1999 ES 9902127 11.11.1999 ES 9902474 (71) Applicant: CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 28006 Madrid (ES)	(72) Inventors: GUTIERREZ-ARMENTA, Crisanto,Cen.de Bio Molecular E-28049 Madrid (ES) RAMIREZ-PARRA, Elena,Centro de Bio Molecular E-28049 Madrid (ES) (74) Representative: Hallybone, Huw George et al Carpmaels and Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)