(19)

(11)

EP 1 216 231 A2

(12)

(88) Date of publication A3: 25.10.2001 (43) Date of publication: 26.06.2002 Bulletin 2002/26 (21) Application number: 00963451.0 (22) Date of filing: 15.09.2000

(51) International Patent Classification (IPC)7: C07D 231/14, C07D 277/56, C07D 401/12, C07D 417/04, A61K 31/33, A61P 7/04 (86) International application number: PCT/US0025/195 (87) International publication number: WO 0119/798 (22.03.2001 Gazette 2001/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.09.1999 US 154332 P (71) Applicant: Millennium Pharmaceuticals, Inc. South San Francisco CA 94080 (US)

(72) Inventors: ZHU, Bing-Yan Belmont, CA 94002 (US) JIA, Zhaozhong, Jon South San Francisco, CA 94080 (US) HUANG, Wenrong Cupertino, CA 95014 (US) SONG, Yonghong Foster City, CA 94404 (US) KANTER, James South San Francisco, CA 94080 (US) SCARBOROUGH, Robert, M. Half Moon Bay, CA 94019 (US) (74) Representative: Clisci, Serge et al S.A. FEDIT-LORIOT & AUTRESCONSEILS EN PROPRIETE INDUSTRIELLE38, Avenue Hoche 75008 Paris 75008 Paris (FR)