(19)

(11)

EP 1 217 992 A1

(12)

(43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00971305.8 (22) Date of filing: 29.09.2000

(51) International Patent Classification (IPC)7: A61K 9/16, A61K 9/28, A61K 9/20 (86) International application number: PCT/EP0009/576 (87) International publication number: WO 0124/777 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.10.1999 GB 9923436 (71) Applicant: AMERICAN HOME PRODUCTS CORPORATION Madison, New Jersey 07940-0874 (US)

(72) Inventors: MUIR, Ian Stuart Waltham Chase,Hampshire SO32 2UD (GB) POTTS, Angela Catherine Titchfield,Hampshire PO14 4NY (GB) ROWLEY, Michael John Titchfield,Hampshire PO15 5EH (GB) SIMS, Edward Eric Bishops Waltham,Hampshire SO32 1DN (GB) WILSON, Christopher Steven Gosport,Hampshire PO12 1QP (GB) (74) Representative: Talbott, Dawn Jacqueline  Wyeth Pharmaceuticals,Taplow Maidenhead SL6 0PH Maidenhead SL6 0PH (GB)