(19)

(11)

EP 1 218 034 A2

(12)

(88) Date of publication A3: 03.01.2002 (43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00969664.2 (22) Date of filing: 04.10.2000

(51) International Patent Classification (IPC)7: A61K 47/48 (86) International application number: PCT/GB0003/792 (87) International publication number: WO 0124/829 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.10.1999 GB 9923337 (71) Applicant: ISIS INNOVATION LIMITED Summertown,Oxford OX2 7BZ (GB)

(72) Inventors: PHILLIPS, Rodney E.,c/o Nuffield Dept of Medicine Headington,Oxford OX3 9DU (GB) DUNBAR, Peter Roderick,Molecular Immunology Group Headington,Oxford OX3 9DS (GB) CERUNDOLO, Vincenzo,Molecular Immunology Group HeadiHeadington,Oxford OX3 9DS (GB) SEWELL, Andrew,Nuffield Department of Medicine Headington,Oxford OX3 9DU (GB) (74) Representative: Lock, Graham James  Fry Heath & Spence,The Old College,53 High Street Horley,Surrey RH6 7BN Horley,Surrey RH6 7BN (GB)