(19)

(11)

EP 1 218 319 A1

(12)

(43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00966100.0 (22) Date of filing: 03.10.2000

(51) International Patent Classification (IPC)7: C07B 61/00, C07C 311/18, C07C 311/41, G01N 21/00 (86) International application number: PCT/EP0009/639 (87) International publication number: WO 0125/171 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.10.1999 GB 9923577 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)

(72) Inventors: CARR, Robin, Arthur, Ellis,Glaxo Wellcome plc Stevenage,Hertfordshire SG1 2NY (GB) GEHANNE, Sylvie,Glaxo Wellcome SpA I-37135 Verona (IT) PAIO, Alfredo,Glaxo Wellcome SpA I-37135 Verona (IT) WILLIAMS, Geoffrey M.,Glaxo Wellcome Chem. Lab. Cambridge CB2 1EW (GB) ZARAMELLA, Alessio,Glaxo Wellcome SpA I-37135 Verona (IT) KAY, Corinne Stevenage, Hertfordshire SG1 2NY (GB) (74) Representative: Filler, Wendy Anne, Dr.  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)