(19)
(11) EP 1 218 486 A1

(12)

(43) Date of publication:
03.07.2002 Bulletin 2002/27

(21) Application number: 00970455.2

(22) Date of filing: 15.09.2000
(51) International Patent Classification (IPC)7: C12N 1/20, C12N 15/00, C12N 15/06, C12N 15/09, C12N 15/16, C12N 15/63, C12N 15/70, C12N 15/74, C07H 21/02, C07H 21/04
(86) International application number:
PCT/US0025/186
(87) International publication number:
WO 0119/959 (22.03.2001 Gazette 2001/12)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 16.09.1999 US 154213 P

(71) Applicant: The Johns-Hopkins University
Baltimore, MD 21218-2695 (US)

(72) Inventors:
  • TOWNSEND, Craig, A.
    Baltimore, MD 21212 (US)
  • LI, Rongfeng
    Baltimore, MD 21218 (US)
  • KHALEELI, Nusrat
    Sunnyvale, CA 94085 (US)

(74) Representative: Lins, Edgar, Dipl.-Phys. Dr.jur. et al
GRAMM, LINS & PARTNERTheodor-Heuss-Strasse 1
38122 Braunschweig
38122 Braunschweig (DE)

   


(54) IMPROVEMENT OF CLAVULANIC ACID PRODUCTION