(19)
(11) EP 1 218 495 A2

(12)

(88) Date of publication A3:
02.05.2002

(43) Date of publication:
03.07.2002 Bulletin 2002/27

(21) Application number: 00993260.9

(22) Date of filing: 04.12.2000
(51) International Patent Classification (IPC)7: C12N 9/68, C07K 1/16
(86) International application number:
PCT/US0032/843
(87) International publication number:
WO 0140/260 (07.06.2001 Gazette 2001/23)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 03.12.1999 US 168919 P

(71) Applicant: EntreMed, Inc.
Rockville, MD 20850 (US)

(72) Inventors:
  • MADSEN, John
    Jefferson, MD 21755 (US)
  • LIANG, Hong
    Gaithersburg, MD 20878 (US)
  • SIM, Kim, Lee
    Gaithersburg, MD 20878 (US)
  • ZHOU, Xinhua
    North Potomac, MD 20878 (US)
  • CHANG-MURAD, Amy
    DeRidder, LA 70634 (US)
  • BOERNER, Renee, J.
    Apex, NC 27513 (US)
  • BERMEJO, Lourdes, L.
    Cary, NC 27513 (US)
  • MISTRY, Firoz, R.
    Chapel Hill, NC 27516 (US)
  • SCHRIMSHER, Jeffrey, L.
    Hillsborough, NC 27278 (US)
  • SHEPARD, Scot, R.
    Clayton, NC 27520 (US)
  • JOHNSTON, Jeremy
    Durham, NC 27713 (US)

(74) Representative: Dey, Michael, Dr. et al
Weickmann & Weickmann,Patentanwälte,Postfach 86 08 20
81635 München
81635 München (DE)

   


(54) METHOD OF PRODUCING AND PURIFYING ANGIOSTATIN$m(3) PROTEIN