(19)

(11)

EP 1 218 499 A2

(12)

(88) Date of publication A3: 17.05.2001 (43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00952452.1 (22) Date of filing: 02.08.2000

(51) International Patent Classification (IPC)7: C12N 15/09, C12N 7/04, A61K 39/165, C07K 14/12, C12N 15/86, C12N 5/10 (86) International application number: PCT/US0021/192 (87) International publication number: WO 0109/309 (08.02.2001 Gazette 2001/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.08.1999 US 146664 P 23.06.2000 US 213654 P (71) Applicant: Wyeth Madison, New Jersey 07940-0874 (US)	(72) Inventors: CLARKE, David, K. Chester, NY 10918 (US) JOHNSON, Erik, J. Tarrytown, NY 10591 (US) SIDHU, Mohinderjit, S. Scotch Plains, NJ 07076 (US) UDEM, Stephen, A. New York, NY 10023 (US) (74) Representative: Wileman, David Francis, Dr.  c/o Wyeth LaboratoriesHuntercombe Lane South TaplowMaidenheadBerkshire SL6 OPH TaplowMaidenheadBerkshire SL6 OPH (GB)