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(11)

EP 1 218 503 A2

(12)

(88) Date of publication A3: 22.11.2001 (43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00965250.4 (22) Date of filing: 21.09.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12N 5/10, C12N 15/62, G01N 33/50, G01N 33/68, C12Q 1/68, C07K 16/28, A61K 47/48 // A61P3:04 (86) International application number: PCT/US0025/891 (87) International publication number: WO 0121/795 (29.03.2001 Gazette 2001/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.09.1999 US 405505 23.09.1999 US 405504 16.12.1999 US 465280 17.02.2000 US 506252 06.07.2000 US 611197 (71) Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH Cambridge, MA 02142 (US) MILLENIUM PHARMACEUTICALS, INC. Cambridge, MA 02139 (US)

(72) Inventors: STAHL, Andreas Allston, MA 02134 (US) HIRSCH, David, J. Jamaica Plain, MA 02130 (US) LODISH, Harvey, F. Brookline, MA 02446 (US) GIMENO, Ruth, E. Wellesley, MA 02481 (US) TARTAGLIA, Louis, A. Newton, MA 02459 (US) (74) Representative: Arends, William Gerrit  Lloyd Wise, Tregear & CoCommonwealth House1-19 New Oxford Street London WC1A 1LW London WC1A 1LW (GB)