(19)

(11)

EP 1 218 522 A2

(12)

(88) Date of publication A3: 18.10.2001 (43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00964402.2 (22) Date of filing: 22.09.2000

(51) International Patent Classification (IPC)7: C12N 15/64, C12N 15/65, C12N 15/70 (86) International application number: PCT/GB0003/655 (87) International publication number: WO 0125/451 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.10.1999 US 157072 P 25.01.2000 GB 0001716 07.09.2000 US 656503 (71) Applicant: TRANSGENOMIC, Inc. San Jose, CA 95131 (US)	(72) Inventors: HORNBY, David, Peter, Joseph,Transgenomic, Ltd. Western Bank,Sheffield S10 2UH (GB) MATIN, Maryam, Moghaddam,Transgenomic, Ltd. Western Bank,Sheffield S10 2UH (GB) (74) Representative: Kremer, Simon Mark et al Mewburn Ellis,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)