(19)

(11)

EP 1 218 523 A1

(12)

(43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00964501.1 (22) Date of filing: 04.10.2000

(51) International Patent Classification (IPC)7: C12N 15/64, C12N 15/85, C12N 5/10, A61K 31/70, A61K 48/00 (86) International application number: PCT/GB0003/806 (87) International publication number: WO 0125/452 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.10.1999 GB 9923381 (71) Applicant: Brosens, Jan London W6 0DU (GB)	(72) Inventor: Brosens, Jan London W6 0DU (GB) (74) Representative: Gardner, Rebecca  Frank B. Dehn & Co.179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)