(19)

(11)

EP 1 218 527 A2

(12)

(88) Date of publication A3: 30.08.2001 (43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00946890.1 (22) Date of filing: 28.06.2000

(51) International Patent Classification (IPC)7: C12N 15/861, C12N 15/28, C12N 15/55, A61K 48/00 (86) International application number: PCT/US0017/856 (87) International publication number: WO 0102/540 (11.01.2001 Gazette 2001/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.07.1999 US 347604 (71) Applicant: ONYX PHARMACEUTICALS, INC. Richmond, CA 94806 (US)	(72) Inventors: HERMISTON, Terry Corte Madera, CA 94925 (US) HAWKINS, Lynda, K. Richmond, CA 94806 (US) JOHNSON, Leisa Lafayette, CA 94549 (US) (74) Representative: Cripps, Joanna Elizabeth et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)