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(11)

EP 1 218 528 A1

(12)

(43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00964529.2 (22) Date of filing: 05.10.2000

(51) International Patent Classification (IPC)7: C12N 15/867, C12N 15/90, C12N 5/10, C12N 7/01, A61K 48/00 (86) International application number: PCT/GB0003/837 (87) International publication number: WO 0125/466 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.10.1999 GB 9923558 (71) Applicant: Oxford Biomedica (UK) Limited Oxford 0X4 4GA (GB)

(72) Inventors: SLINGSBY, Jason PutneyLondon SW15 1NR (GB) KINGSMAN, Susan, MaryOxford BioMedica (UK) Ltd. The Oxford SCience ParkOxford OX4 4GA (GB) ROHLL, JonathanOxford BioMedica (UK) LTD. The Oxford Science ParkOxford OX4 4GA (GB) SLADE, AndrewOxford BioMedica (UK) Ltd. The Oxford Science PakOxford OX4 4GA (GB) (74) Representative: Harding, Charles Thomas  D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)