(19)

(11)

EP 1 218 753 A2

(12)

(88) Date of publication A3: 07.06.2001 (43) Date of publication: 03.07.2002 Bulletin 2002/27 (21) Application number: 00965455.9 (22) Date of filing: 26.09.2000

(51) International Patent Classification (IPC)7: G01N 33/86 (86) International application number: PCT/US0026/438 (87) International publication number: WO 0123/895 (05.04.2001 Gazette 2001/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.09.1999 US 156564 P (71) Applicant: Oklahoma Medical Research Foundation Oklahoma CityOklahoma 73104 (US)	(72) Inventors: ESMON, Naomi, L. Oklahoma City, OK 73111 (US) SAFA JAMILABADI, Omid Oklahoma City, OK 73120 (US) (74) Representative: UEXKÜLL & STOLBERG  PatentanwälteBeselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)