(19)

(11)

EP 1 220 673 A2

(12)

(88) Date of publication A3: 10.01.2002 (43) Date of publication: 10.07.2002 Bulletin 2002/28 (21) Application number: 00967281.7 (22) Date of filing: 03.10.2000

(51) International Patent Classification (IPC)7: A61K 31/5375, A61P 3/04 (86) International application number: PCT/US0027/252 (87) International publication number: WO 0126/641 (19.04.2001 Gazette 2001/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.10.1999 GB 9924275 28.01.2000 GB 0001861 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)	(72) Inventors: MATTHEWS, Jessica E,,c/o Glaxo Wellcome Inc. Research Triangle Park, NC 27709 (US) MUSSO, David Lee,c/o Glaxo Smith Kline Research Triangle Park, NC 277 09 (US) (74) Representative: Dolton, Peter Irving Ernest et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)