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(11)

EP 1 220 902 A2

(12)

(88) Date of publication A3: 28.02.2002 (43) Date of publication: 10.07.2002 Bulletin 2002/28 (21) Application number: 00967618.0 (22) Date of filing: 13.10.2000

(51) International Patent Classification (IPC)7: C12N 15/11, A61K 31/7125, A61K 47/48, C12Q 1/68, A61L 2/00 // A61P31:04 (86) International application number: PCT/DK0000/580 (87) International publication number: WO 0127/261 (19.04.2001 Gazette 2001/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.10.1999 DK 146799 13.10.1999 DK 147199 15.10.1999 US 159684 P 15.10.1999 US 159679 P 03.12.1999 DK 173499 03.12.1999 DK 173599 28.03.2000 DK 200000522 19.04.2000 DK 200000671 19.04.2000 DK 200000670 14.06.2000 US 211878 P 14.06.2000 US 211758 P 14.06.2000 US 211435 P (71) Applicant: Pantheco A/S 2100 Copenhagen (DK)

(72) Inventors: NIELSEN, Peter, E. DK-2980 Kokkedal (DK) GOOD, Liam 171 77 Stockholm (SE) HANSEN, Henrik, Frydenlund DK-2610 R dovre (DK) BECK, Frederik DK-1964 Frederiksberg C (DK) MALIK, Leila DK-2400 Copenhagen NV (DK) SCHOU, Carsten 2840 Holte (DK) WISSENBACH, Margit DK-2200 Copenhagen N (DK) GIWERCMAN, Birgit Kjaeldgaard DK-2920 Charlottenlund (DK) (74) Representative: Olsen, Lars Pallisgaard et al Hofman-Bang Zacco A/SHans Bekkevolds Allé 7 2900 Hellerup 2900 Hellerup (DK)