(19)

(11)

EP 1 220 916 A1

(12)

(43) Date of publication: 10.07.2002 Bulletin 2002/28 (21) Application number: 00968431.7 (22) Date of filing: 27.09.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C07K 14/47, C07K 16/18, C12Q 1/68, A61K 38/17 (86) International application number: PCT/US0026/544 (87) International publication number: WO 0123/564 (05.04.2001 Gazette 2001/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.09.1999 US 156280 P (71) Applicant: Scios Inc. Sunnyvale, CA 94085 (US)	(72) Inventors: STANTON, Lawrence, W. Redwood, CA 94062 (US) KAPOUN, Ann, M. Palo Alto, CA 94306 (US) (74) Representative: Bohmann, Armin K., Dr.  Bohmann & Loosen,Anwaltssozietät,Sonnenstrasse 8 80331 München 80331 München (DE)