(19)
(11) EP 1 221 283 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
04.03.2009 Bulletin 2009/10

(45) Mention of the grant of the patent:
03.09.2008 Bulletin 2008/36

(21) Application number: 01309893.4

(22) Date of filing: 22.11.2001
(51) International Patent Classification (IPC): 
A01K 67/027(2006.01)
C12N 5/10(2006.01)
C12N 15/85(2006.01)
 C12N 5/06(2006.01)
C12N 15/63(2006.01)
A61K 49/00(2006.01)

(54)

Transgenic animal for screening therapeutic agents for brain tumors

Transgenes Tier zum Testen von therapeutischen Wirkstoffen wirksam gegen Gehirntumore

Animal transgénique pour le criblage d'agents thérapeutiques contre des tumeurs cérébrales

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

(30) Priority: 22.11.2000 US 252745 P

(43) Date of publication of application:
10.07.2002 Bulletin 2002/28

(73) Proprietor: Chiu, Ing-Ming
Taipei 106 (TW)

(72) Inventor:
  • Chiu, Ing-Ming
    Taipei 106 (TW)

(74) Representative: Woods, Geoffrey Corlett 
J.A. KEMP & CO. 14 South Square
Gray's Inn London WC1R 5JJ
Gray's Inn London WC1R 5JJ (GB)


(56) References cited: : 
US-A- 5 980 885
   
  • FUNG KAR-MING ET AL: "Animal models of medulloblastomas and related primitive neuroectodermal tumors: A review." JOURNAL OF NEUROPATHOLOGY & EXPERIMENTAL NEUROLOGY, vol. 54, no. 3, 1995, pages 285-296, XP008022557 ISSN: 0022-3069
  • RAY SUBIR KUMAR ET AL: "Transcriptional activation of fibroblast growth factor 1.B promoter is mediated through an 18-base pair cis-acting element." JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 11, 1997, pages 7546-7555, XP002256106 ISSN: 0021-9258
  • REYNOLDS B A ET AL: "GENERATION OF NEURONS AND ASTROCYTES FROM ISOLATED CELLS OF THE ADULT MAMMALIAN CENTRAL NERVOUS SYSTEM" SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 255, no. 5052, 27 March 1992 (1992-03-27), pages 1707-1710, XP000561246 ISSN: 0036-8075
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).