(19)
(11) EP 1 222 202 A2

(12)

(88) Date of publication A3:
17.01.2002

(43) Date of publication:
17.07.2002 Bulletin 2002/29

(21) Application number: 00968795.5

(22) Date of filing: 05.10.2000
(51) International Patent Classification (IPC)7: C07K 14/28, C07K 14/245, C07K 14/25, C07K 14/235, C12N 15/31, C12N 5/10, A61K 39/106, A61K 39/112, A61K 39/10, A61K 39/108
(86) International application number:
PCT/US0027/607
(87) International publication number:
WO 0127/144 (19.04.2001 Gazette 2001/16)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 08.10.1999 US 158561 P

(71) Applicant: Active Biotech AB
220 07 Lund (SE)

(72) Inventors:
  • HANDLEY, Harold, H.
    Encinitas, CA 92024 (US)
  • HAAPARANTA, Tapio
    San Diego, CA 92120 (US)
  • EWALT, Karla, L.
    San Diego, CA 92122 (US)

(74) Representative: Woods, Geoffrey Corlett 
J.A. KEMP & CO.Gray's Inn14 South Square
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) AB5 TOXIN B SUBUNIT MUTANTS WITH ALTERED CHEMICAL CONJUG ATION CHARACTERISTICS