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EP 1 222 203 A1

(12)

(43) Date of publication: 17.07.2002 Bulletin 2002/29 (21) Application number: 00968122.2 (22) Date of filing: 16.10.2000

(51) International Patent Classification (IPC)7: C07K 14/47, C07K 14/54, C12N 15/11, C12N 15/63, A61P 25/00, A61K 38/17 (86) International application number: PCT/GB0003/974 (87) International publication number: WO 0127/152 (19.04.2001 Gazette 2001/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.10.1999 GB 9924484 (71) Applicant: ISIS INNOVATION LIMITED Summertown,Oxford OX2 7BZ (GB)

(72) Inventors: Villegas, VirtudesDept. de B.B.M.Unitat de Cien. 08193 Bellaterra (ES) Zurdo, JesusOxford Centre for Molecular Sciences Oxford OX1 3QT (GB) Aviles, FrancescDept de B.B.M.Unitat de Ciencies 08193 Bellaterra (ES) Dobson, Christopher M.Oxford Centre for Mol. Sci. Oxford OX1 3QT (GB) Serrano, Luis 69117 Heidelberg (DE) (74) Representative: Roques, Sarah Elizabeth  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)