(19)

(11)

EP 1 222 272 A2

(12)

(88) Date of publication A3: 10.01.2002 (43) Date of publication: 17.07.2002 Bulletin 2002/29 (21) Application number: 00973541.6 (22) Date of filing: 13.10.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/16, C07K 14/575, C07K 14/705, C07K 14/47, G01N 33/68, C12Q 1/68, C07K 16/18, C07K 16/26, C07K 16/28, C12N 5/10, A61K 31/7088, A61K 38/17, A61K 38/22, A61K 39/395, A61K 48/00 (86) International application number: PCT/US0028/474 (87) International publication number: WO 0129/217 (26.04.2001 Gazette 2001/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.10.1999 US 159805 P 18.10.1999 US 159992 P 22.10.1999 US 160952 P 12.10.2000 US  (71) Applicant: Curagen Corporation New Haven, CT 06511 (US)	(72) Inventors: PRAYAGA, Sudhirdas, K. East Haven, CT 06512 (US) TAUPIER, Raymond, J., Jr. East Haven, CT 06512 (US) BANDARU, Raj New Haven, CT 06511 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)