(19)

(11)

EP 1 222 278 A1

(12)

(43) Date of publication: 17.07.2002 Bulletin 2002/29 (21) Application number: 99951879.8 (22) Date of filing: 08.10.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/11, C07K 14/47, C07K 16/18, C12Q 1/68, A61K 38/17, A61P 27/06, A01K 67/027, G01N 33/50, G01N 33/53 (86) International application number: PCT/US9923/516 (87) International publication number: WO 0127/272 (19.04.2001 Gazette 2001/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (71) Applicant: Matsuo, Toshihiko Okayama City 700-0015 (JP)	(72) Inventor: Matsuo, Toshihiko Okayama City 700-0015 (JP) (74) Representative: Kirkham, Nicholas Andrew  Graham Watt & Co.St. Botolph's House7-9 St. Botolph's Road SevenoaksKent TN13 3AJ SevenoaksKent TN13 3AJ (GB)