(19)

(11)

EP 1 223 919 A1

(12)

(43) Date of publication: 24.07.2002 Bulletin 2002/30 (21) Application number: 00980085.5 (22) Date of filing: 27.10.2000

(51) International Patent Classification (IPC)7: A61K 9/20, A61K 9/48 (86) International application number: PCT/NL0000/779 (87) International publication number: WO 0130/322 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.10.1999 EP 99203578 (71) Applicant: Universiteit Leiden 2300 RA Leiden (NL)	(72) Inventors: JUNGINGER, Hans, Eugen NL-2324 JN Leiden (NL) VERHOEF, Jacobus NL-3721 BW Bilthoven (NL) BORCHARD, Gerrit NL-2353 SE Leiderdorp (NL) DORKOOSH, Farid, Abedin NL-2334 EA Leiden (NL) RAFIEE-TEHRANI, Mort Teheran (IR) (74) Representative: Prins, Adrianus Willem et al Vereenigde,Nieuwe Parklaan 97 2587 BN Den Haag 2587 BN Den Haag (NL)