(19)

(11)

EP 1 223 939 A1

(12)

(43) Date of publication: 24.07.2002 Bulletin 2002/30 (21) Application number: 00927593.4 (22) Date of filing: 16.05.2000

(51) International Patent Classification (IPC)7: A61K 31/551, A61K 31/554, A61P 3/04, A61P 25/18 (86) International application number: PCT/GB0001/875 (87) International publication number: WO 0071/106 (30.11.2000 Gazette 2000/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.05.1999 GB 9911499 08.02.2000 GB 0002762 (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventors: REINSTEIN, Michael, J.,Forest Hospital/Rush Pres. Chicago, IL 6040 (US) JONES, Andrew, Martin Cheshire SK10 4TG (GB)