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(11)

EP 1 224 171 A1

(12)

(43) Date of publication: 24.07.2002 Bulletin 2002/30 (21) Application number: 00970820.7 (22) Date of filing: 12.10.2000

(51) International Patent Classification (IPC)7: C07D 213/70, C07D 239/38, C07D 277/36, C07D 233/84, C07D 263/46, C07D 249/12, C07D 213/32, C07D 263/32, C07D 213/76, C07D 333/18, A61K 31/18, A61K 31/505 (86) International application number: PCT/US0028/194 (87) International publication number: WO 0127/084 (19.04.2001 Gazette 2001/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.10.1999 US 159320 P (71) Applicant: THE PROCTER & GAMBLE COMPANY Cincinnati,Ohio 45202 (US)

(72) Inventors: PIKUL, Stanislaw Mason, OH 45040 (US) OHLER, Norman, Eugene Loveland, OH 45140 (US) SOLINSKY, Kelly, Michelle Cincinnati, OH 45208 (US) ALMSTEAD, Neil, Gregory Loveland, OH 45140 (US) DE, Biswanath Cincinnati, OH 45241 (US) NATCHUS, Michael, George Glendale, OH 45246 (US) (74) Representative: Nargolwalla, Cyra et al Cabinet Plasseraud84, rue d'Amsterdam 75440 Paris Cedex 09 75440 Paris Cedex 09 (FR)