(19)

(11)

EP 1 224 281 A1

(12)

(43) Date of publication: 24.07.2002 Bulletin 2002/30 (21) Application number: 00966856.7 (22) Date of filing: 26.09.2000

(51) International Patent Classification (IPC)7: C12N 15/11, C12Q 1/68, C07K 7/06 (86) International application number: PCT/US0026/323 (87) International publication number: WO 0123/546 (05.04.2001 Gazette 2001/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.09.1999 US 155805 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20878 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven,-M. Olney, MD 20832 (US) KOMATSOULIS, George, A. Silver Spring, MD 20901 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)