(19)

(11)

EP 1 224 301 A2

(12)

(88) Date of publication A3: 02.05.2002 (43) Date of publication: 24.07.2002 Bulletin 2002/30 (21) Application number: 00964542.5 (22) Date of filing: 09.10.2000

(51) International Patent Classification (IPC)7: C12N 15/62, C07K 19/00, C12N 15/12, C07K 14/475, C12N 15/10, C12N 7/01, C12Q 1/70, G01N 33/68, C12N 15/86, A61K 48/00 (86) International application number: PCT/GB0003/858 (87) International publication number: WO 0127/292 (19.04.2001 Gazette 2001/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.10.1999 US 415565 (71) Applicant: Biofocus Discovery Limited Cambridge CB4 4FD (GB)

(72) Inventors: CHADWICK, Mark Philip HaverhillSuffolk CB9 7WS (GB) BELCHER, Craig SandyBedfordshire SG19 1NL (GB) GLENN, Daphne Cambridge CB1 7SS (GB) BULLOUGH, Frances Joanne Cherry HintonCambridge CB1 4SA (GB) RUSSELL, Stephen, James Rochester, MN 55902 (US) (74) Representative: Lipscombe, Martin John et al Keith W Nash & Co,Pearl Assurance House,90-92 Regent Street Cambridge CB2 1DP Cambridge CB2 1DP (GB)