(19)

(11)

EP 1 225 866 A2

(12)

(88) Date of publication A3: 06.12.2001 (43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00975533.1 (22) Date of filing: 01.11.2000

(51) International Patent Classification (IPC)7: A61K 6/00 (86) International application number: PCT/US0030/113 (87) International publication number: WO 0132/127 (10.05.2001 Gazette 2001/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.11.1999 US 163158 P (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)	(72) Inventors: GOODFELLOW,Peter,N.New Frontiers Scie.Park South Essex CM19 5AW (GB) NIEMAN, Richard Philadelphia, PA 19118 (US) TORPHY, Theodore, J. Bryn Mawr, PA 19010 (US) (74) Representative: Thompson, Clive Beresford et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)