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EP 1 225 886 A2

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(88) Date of publication A3: 30.05.2002 (43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00939471.9 (22) Date of filing: 31.05.2000

(51) International Patent Classification (IPC)7: A61K 31/195, A61K 31/415, A61K 31/40, A61K 31/425, A61K 31/445, A61K 31/41, A61K 31/36, A61P 25/28, C07D 233/54, C07D 295/12, C07D 207/327, C07D 277/36 (86) International application number: PCT/US0015/071 (87) International publication number: WO 0076/489 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.06.1999 US 138550 P (71) Applicants: WARNER-LAMBERT COMPANY Morris PlainsNew Jersey 07950 (US) Yamanouchi Pharmaceutical Company Ltd. Tokyo 174-8612 (JP)

(72) Inventors: AUGELLI-SZAFRAN, Corinne Elizabeth Ann Arbor, MI 48103 (US) BARVIAN, Mark Robert Ann Arbor, MI 48103 (US) BIGGE, Christopher Franklin Ann Arbor, MI 48105 (US) GLASE, Shelly Ann Ann Arbor, MI 48105 (US) HACHIYA, Shunichiro Tsukuba, Ibaraki 305-0051 (JP) KEILY, John Steven San Diego, CA 92130 (US) KIMURA, Takenori Tsukuba,Ibaraki 305-0045 (JP) LAI, Yingjie Edison, NJ 08817 (US) SAKKAB, Annette Theresa Northville, MI 48167 (US) SUTO, Mark James La Jolla, CA 92037 (US) WALKER, Lary Craswell Ann Arbor, MI 48105 (US) YASUNAGA, Tomoyuki Ushiku-shi,Ibaraki 300-1222 (JP) ZHUANG, Nian Ypsilanti, MI 48197 (US) (74) Representative: Mansmann, Ivo et al Warner-Lambert Company,Patent Department,c/o Gödecke GmbH 79090 Freiburg 79090 Freiburg (DE)