(19)

(11)

EP 1 225 888 A2

(12)

(88) Date of publication A3: 21.02.2002 (43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00982701.5 (22) Date of filing: 19.10.2000

(51) International Patent Classification (IPC)7: A61K 31/195, A61K 31/16, A61K 31/19, A61K 31/60, A61K 31/22, A61K 31/165, A61K 31/18, A61K 31/255, A61K 31/27, A61K 9/28, A61K 9/50 (86) International application number: PCT/US0041/267 (87) International publication number: WO 0128/516 (26.04.2001 Gazette 2001/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.10.1999 US 160210 P (71) Applicant: NPS PHARMACEUTICALS, INC. Salt Lake CityUtah 84108 (US)	(72) Inventors: WELLS, David, S. Sandy, UT 84093 (US) MARRIOTT, Thomas, B. Sandy, UT 84121 (US) RAJEWSKI, Lian, G. Lawrence, KS 66047 (US) PIPKIN, James, D. Lawrence, KS 66049 (US) HASLAM, John, L. Lawrence, KS 66046 (US) (74) Representative: Plougmann & Vingtoft A/S  Sankt Annae Plads 11P.O.Box 3007 1021 Copenhagen K 1021 Copenhagen K (DK)