(19)

(11)

EP 1 225 910 A2

(12)

(88) Date of publication A3: 14.02.2002 (43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00980281.0 (22) Date of filing: 02.11.2000

(51) International Patent Classification (IPC)7: A61K 38/18, A61P 9/04, A61P 9/10, A61P 9/12 (86) International application number: PCT/US0030/294 (87) International publication number: WO 0132/695 (10.05.2001 Gazette 2001/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.11.1999 US 163132 P (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)	(72) Inventors: SHEN, Ben-Quan San Francisco, CA 94116 (US) ZIONCHECK, Thomas Montara, CA 94037 (US) (74) Representative: Cripps, Joanna Elizabeth et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)