(19)
(11) EP 1 225 914 A2

(12)

(88) Date of publication A3:
03.05.2001

(43) Date of publication:
31.07.2002 Bulletin 2002/31

(21) Application number: 00939712.6

(22) Date of filing: 09.06.2000
(51) International Patent Classification (IPC)7A61K 39/00, A61K 38/19, A61K 48/00, A61P 33/06, C12N 15/86
(86) International application number:
PCT/US0015/839
(87) International publication number:
WO 0076/539 (21.12.2000 Gazette 2000/51)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 11.06.1999 US 138603 P

(71) Applicants:
  • US Government as represented by the Secretary of the Navy
    Silver Spring, MD 20910 (US)
  • Hoffman, Stephen
    Silver Spring, MD 20910 (US)
  • Hedstrom, Richard
    Tannersville, PA 18372 (US)
  • Sedegah, Martha
    Silver Spring, MD 20910 (US)
  • Weiss, Walter
    Silver Spring, MD 20910 (US)

(72) Inventors:
  • HOFFMAN, Stephen,Naval Medical Research Center
    Silver Spring, MD 20910 (US)
  • HEDSTROM, Richard
    Tannersville, PA 18372 (US)
  • SEDEGAH, Martha,Naval Medical Research Center
    Silver Spring, MD 20910 (US)
  • WEISS, Walter,Naval Medical Research Center
    Silver Spring, MD 20910 (US)

(74) Representative: HOFFMANN - EITLE 
Patent- und RechtsanwälteArabellastrasse 4
81925 München
81925 München (DE)

   


(54) A METHOD TO IMPROVE PROTECTIVE IMMUNITY INDUCED BY POLYNUCLEOTIDE VACCINES