(19)

(11)

EP 1 225 921 A1

(12)

(43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00976894.6 (22) Date of filing: 03.11.2000

(51) International Patent Classification (IPC)7: A61K 48/00, A61K 38/18, C07K 14/50, C07K 14/49, A61P 9/00, A61P 9/04, A61P 9/10 (86) International application number: PCT/US0030/345 (87) International publication number: WO 0134/208 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.11.1999 US 435156 30.06.2000 US 609080 (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: HAMMOND, H., Kirk La Jolla, CA 92037 (US) GIORDANO, Frank, J. Del Mar, CA 92014 (US) DILLMANN, Wolfgang, H. Solana Beach, CA 92075 (US) (74) Representative: Campbell, Patrick John Henry  J.A. Kemp & Co.,14 South Square,Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)