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EP 1 226 152 A2

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(88) Date of publication A3: 10.05.2002 (43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00975448.2 (22) Date of filing: 26.10.2000

(51) International Patent Classification (IPC)7: C07H 21/04, C07K 2/00, C07K 4/00, C12N 1/20, C12N 15/09, C12N 15/63, C12N 15/74, C12P 21/00, C12P 21/04, C12P 21/06 (86) International application number: PCT/US0029/690 (87) International publication number: WO 0130/972 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.10.1999 US 161379 P (71) Applicant: Digital Gene Technologies Inc. La Jolla, CA 90237 (US)

(72) Inventors: THOMAS, Elizabeth, A. Cardiff, CA 92007 (US) SUTCLIFFE, J., Gregor Cardiff-by-the-sea, CA 92007 (US) PRIBYL, Thomas, M. San Diego, CA 92109 (US) HILBUSH, Brian San Diego, CA 92130 (US) HASEL, Karl, W. Soloana Beach, CA 92075 (US) (74) Representative: Kaiser, Jürgen, Dr.rer.nat.Dipl.-Chem. et al Winter, Brandl, Fürniss, Hübner,Röss, Kaiser, PoltePartnerschaftPatent- und RechtsanwaltskanzleiAlois-Steinecker-Strasse 22 85354 Freising 85354 Freising (DE)