(19)

(11)

EP 1 226 161 A2

(12)

(88) Date of publication A3: 17.05.2001 (43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00963542.6 (22) Date of filing: 14.09.2000

(51) International Patent Classification (IPC)7: C07K 14/00 (86) International application number: PCT/US0025/436 (87) International publication number: WO 0119/861 (22.03.2001 Gazette 2001/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.09.1999 US 396710 (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)	(72) Inventors: ASHKENAZI, Avi, J. San Mateo, CA 94402 (US) CHUNTHERAPAI, Anan Colma, CA 94015 (US) KIM, K., Jin Los Altos, CA 94024 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)