(19)

(11)

EP 1 226 245 A2

(12)

(88) Date of publication A3: 01.11.2001 (43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00973001.1 (22) Date of filing: 01.11.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C07K 14/705, A61K 31/7088, A61K 38/17, A61K 48/00 (86) International application number: PCT/GB0004/189 (87) International publication number: WO 0132/866 (10.05.2001 Gazette 2001/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.11.1999 GB 9925854 (71) Applicant: Celltech R&D Limited Slough,Berkshire SL1 3WE (GB)	(72) Inventors: FINNEY, Helene Margaret Berkshire SL6 4DQ (GB) LAWSON, Alastair, David Griffiths Hampshire SO2 0NX (GB) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)