(19)

(11)

EP 1 226 282 A2

(12)

(88) Date of publication A3: 30.05.2002 (43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00947102.0 (22) Date of filing: 06.07.2000

(51) International Patent Classification (IPC)7: C12Q 1/70, C12Q 1/68, C07K 14/15, C12N 15/867 (86) International application number: PCT/US0018/597 (87) International publication number: WO 0104/360 (18.01.2001 Gazette 2001/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.07.1999 US 143015 P 10.11.1999 US 164626 P (71) Applicants: UAB RESEARCH FOUNDATION Birmingham,Alabama 35294 (US) Tranzyme, Inc. Birmingham, AL 35209 (US)	(72) Inventors: KAPPES, John, C. Birmingham, AL 35242 (US) WU, Xiaoyun Birmingham, AL 35242 (US) WAKEIELD, John Birmingham, AL 35222 (US) (74) Representative: Bryer, Kenneth Robert et al K.R. Bryer & Co.7 Gay Street Bath BA1 2PH Bath BA1 2PH (GB)