(19)

(11)

EP 1 226 439 A1

(12)

(43) Date of publication: 31.07.2002 Bulletin 2002/31 (21) Application number: 00984990.2 (22) Date of filing: 01.11.2000

(51) International Patent Classification (IPC)7: G01N 33/574 (86) International application number: PCT/EP0011/050 (87) International publication number: WO 0133/229 (10.05.2001 Gazette 2001/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.11.1999 EP 99203582 (71) Applicant: Universiteit van Amsterdam 1012 WX Amsterdam (NL)	(72) Inventor: VAN DRIEL, Roeland,Universiteit van Amsterdam 1018 TV Amsterdam (NL) (74) Representative: Huygens, Arthur Victor  Octrooibureau Huygens,P.O. Box 86 3400 AB Ijsselstein 3400 AB Ijsselstein (NL)