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EP 1 227 722 A1

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(43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00975482.1 (22) Date of filing: 27.10.2000

(51) International Patent Classification (IPC)7: A01N 37/00, A01N 37/10, A01N 37/30, A01N 37/44, A01N 43/02, A01N 43/16, A01N 43/64, A01N 57/00, C07C 63/313, C07C 57/34, C07D 211/70, C07D 239/02, C07D 307/02 (86) International application number: PCT/US0029/867 (87) International publication number: WO 0130/149 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.10.1999 US 162369 P (71) Applicant: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US)

(72) Inventors: BALKOVEC, James, M. Rahway, NJ 07065-0907 (US) HAMMOND, Gail Rahway, NJ 07065-0907 (US) GREENLEE, Mark, L. Rahway, NJ 07065-0907 (US) OLSON, Steven, H. Rahway, NJ 07065-0907 (US) ROUEN, Gregory, P. Rahway, NJ 07065-0907 (US) EPSTEIN-TONEY, Jeffrey, H. Rahway, NJ 07065-0907 (US) (74) Representative: Hiscock, Ian James et al European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)