(19)

(11)

EP 1 227 785 A2

(12)

(88) Date of publication A3: 06.06.2002 (43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00940800.6 (22) Date of filing: 22.06.2000

(51) International Patent Classification (IPC)7: A61K 7/13 (86) International application number: PCT/JP0004/088 (87) International publication number: WO 0078/273 (28.12.2000 Gazette 2000/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.06.1999 JP 17516899 (71) Applicant: Lion Corporation Tokyo 130-8644 (JP)	(72) Inventors: ONUKI, Takeshi Tokyo 130-8644 (JP) NOGUCHI, Mutsumi Tokyo 130-8644 (JP) MITAMURA, Joji Tokyo 130-8644 (JP) (74) Representative: Stuart, Ian Alexander et al MEWBURN ELLISYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)