| (84) |
Designated Contracting States: |
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AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
| (30) |
Priority: |
12.11.1999 US 164768 P
12.11.1999 US 164765 P
|
| (43) |
Date of publication of application: |
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07.08.2002 Bulletin 2002/32 |
| (60) |
Divisional application: |
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06012623.2 |
| (73) |
Proprietor: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
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Baltimore, MD 21202 (US) |
|
| (72) |
Inventors: |
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- PIZER, Ellen, S.
Columbia, MD 21029 (US)
- TOWNSEND, Craig, A.
Baltimore, MD 21212 (US)
- KUHAJDA, Francis, P.
Lutherville, MD 21209 (US)
|
| (74) |
Representative: Dean, John Paul et al |
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Withers & Rogers LLP
Goldings House,
2 Hays Lane
London SE1 2HW
London SE1 2HW (GB) |
| (56) |
References cited: :
US-A- 5 539 132
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US-A- 5 759 837
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- PIZER ELLEN S ET AL: "Inhibition of fatty acid synthesis induces programmed cell death
in human breast cancer cells." CANCER RESEARCH, vol. 56, no. 12, 1996, pages 2745-2747,
XP000942097 ISSN: 0008-5472
- KUHAJDA, F. P. (1) ET AL: "Synthesis and anti- tumor activity of a novel inhibitor
of fatty acid synthase." PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH
ANNUAL MEETING, (MARCH, 1999) VOL. 40, PP. 121. MEETING INFO.: 90TH ANNUAL MEETING
OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH PHILADELPHIA, PENNSYLVANIA, USA APRIL
10-14, 1999 AMERICAN , XP000942098
- PIZER E S ET AL: "Fatty acid synthase (FAS): a target for cytotoxic antimetabolites
in HL60 promyelocytic leukemia cells." CANCER RESEARCH, (1996 FEB 15) 56 (4) 745-51.
, XP000942096
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synthesis and palmitate-induced apoptosis." JOURNAL OF BIOLOGICAL CHEMISTRY, vol.
272, no. 6, 1997, pages 3324-3329, XP000942110 ISSN: 0021-9258 cited in the application
- HENNIGAR RANDOLPH A ET AL: "Characterization of fatty acid synthase in cell lines
derived from experimental mammary tumors." BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1392,
no. 1, 20 May 1998 (1998-05-20), pages 85-100, XP000942091 ISSN: 0006-3002
- PIZER ELLEN S ET AL: "Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced
by fatty acid synthase inhibition in human breast cancer cell and xenografts." CANCER
RESEARCH, vol. 60, 15 January 2000 (2000-01-15), pages 213-218, XP000983309 ISSN:
0197-016X
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