(19)

(11)

EP 1 227 839 A2

(12)

(88) Date of publication A3: 08.11.2001 (43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00975694.1 (22) Date of filing: 10.11.2000

(51) International Patent Classification (IPC)7: A61K 39/108, A61K 39/112, A61K 39/02, A61P 31/04 (86) International application number: PCT/CA0001/321 (87) International publication number: WO 0134/190 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.11.1999 US 164564 P 21.03.2000 US 190934 P (71) Applicant: NATIONAL RESEARCH COUNCIL OF CANADA Ottawa,Ontario K1A 0R6 (CA)	(72) Inventors: PERRY, Malcolm, B. Ottawa, Ontario K1K 0K6 (CA) CONLAN, J., Wayne Orleans, Ontario K1C 2M7 (CA) (74) Representative: Jackson, Derek Charles  Derek Jackson Associates,The Old Yard,Lower Town Claines,Worcester WR3 7RY Claines,Worcester WR3 7RY (GB)