(19)
(11) EP 1 227 842 A1

(12)

(43) Date of publication:
07.08.2002 Bulletin 2002/32

(21) Application number: 00980341.2

(22) Date of filing: 10.11.2000
(51) International Patent Classification (IPC)7A61K 39/395, A61K 39/40, A61K 39/42
(86) International application number:
PCT/US0030/975
(87) International publication number:
WO 0134/195 (17.05.2001 Gazette 2001/20)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 12.11.1999 US 165165 P

(71) Applicants:
  • Temple University of the CommonwealthSystem of Higher Education
    PhiladelphiaPA 19122 (US)
  • DuPont Pharmaceuticals Company
    Wilmington,Delaware 19805 (US)

(72) Inventors:
  • COLMAN, Robert, W.
    Moylan, PA 19065 (US)
  • MOUSA, Shaker, A.
    New London, PA 19352 (US)

(74) Representative: McNally, Roisin et al
Murgitroyd & Company165-169 Scotland Street
Glasgow G5 8PL
Glasgow G5 8PL (GB)

   


(54) INHIBITION OF ANGIOGENESIS BY ANTIBODIES AGAINST HIGH MOLECULAR WEIGHT KININOGEN DOMAIN 5