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(11)

EP 1 227 849 A2

(12)

(88) Date of publication A3: 06.06.2002 (43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 01922246.2 (22) Date of filing: 23.02.2001

(51) International Patent Classification (IPC)7: A61K 51/04, A61K 51/10 (86) International application number: PCT/US0105/927 (87) International publication number: WO 0166/155 (13.09.2001 Gazette 2001/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.02.2000 US 185220 P (71) Applicants: Ma, Dangshe Rockville, MD 20851 (US) McDevitt, Michael R. Bronx, NY 10471 (US) Scheinberg, David A. New York, NY 10025 (US) Simon, Jaime Angleton, TX 77515 (US) Kiefer, Garry E. Lake Jackson, TX 77566 (US) Franck, R. Keith Lake Jackson, TX 77566 (US) Gulyas, Gyongyi Lake Jackson, TX 77566 (US)

(72) Inventors: Ma, Dangshe Rockville, MD 20851 (US) McDevitt, Michael R. Bronx, NY 10471 (US) Scheinberg, David A. New York, NY 10025 (US) Simon, Jaime Angleton, TX 77515 (US) Kiefer, Garry E. Lake Jackson, TX 77566 (US) Franck, R. Keith Lake Jackson, TX 77566 (US) Gulyas, Gyongyi Lake Jackson, TX 77566 (US) (74) Representative: Raynor, John et al W.H. Beck, Greener & Co7 Stone BuildingsLincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)