(19)

(11)

EP 1 228 045 A2

(12)

(88) Date of publication A3: 21.02.2002 (43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00973917.8 (22) Date of filing: 26.10.2000

(51) International Patent Classification (IPC)7: C07D 237/26, A61K 31/502, A61K 31/5025, A61P 35/00, C07D 491/04, C07D 471/04, C07D 487/04, C07D 471/14 // (C07D491/04, 317:00), C07D237:00,(C07D471/04, 237:00), C07D221:00 (86) International application number: PCT/US0029/583 (87) International publication number: WO 0132/631 (10.05.2001 Gazette 2001/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.10.1999 US 162540 P (71) Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY New Brunswick, NJ 08903 (US)	(72) Inventors: LAVOIE, Edmond, J. Princeton Junction, NJ 08550 (US) LIU, Leroy, Fong Bridgewater, NJ 08807 (US) YU, Younong Piscataway, NJ 08854 (US) (74) Representative: Calamita, Roberto  Frank B. Dehn & Co.,European Patent Attorneys,179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)