(19)

(11)

EP 1 228 051 A1

(12)

(43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00976915.9 (22) Date of filing: 03.11.2000

(51) International Patent Classification (IPC)7: C07D 277/36, C07D 417/12, C07D 403/12, A61K 31/426, A61K 31/427, A61K 31/4178, A61P 7/00 (86) International application number: PCT/US0030/383 (87) International publication number: WO 0134/585 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 05.11.1999 US 163907 P (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)	(72) Inventors: LUENGO, Juan, I. Audubon, PA 19403 (US) DUFFY, Kevin, J. Norristown, PA 19403 (US) SHAW, Antony Chester Springs, PA 19425 (US) (74) Representative: Thompson, Clive Beresford et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)